Soil: Mulberries like a warm, well-drained soil, preferably a deep loam. Shallow soils such as those frequently found on chalk or gravel are not recommended.
Irrigation: Although somewhat drought-resistant, mulberries need to be watered in dry seasons. If the roots become too dry during drought, the fruit is likely to drop before it has fully ripened.

Fertilization: Mulberries generally thrive with minimal fertilization. An annual application of a balanced fertilizer such as 10:10:10 will maintain satisfactory growth. In California mulberries usually need only nitrogen.

Pruning: No special pruning techniques are needed after the branches have been trained to a sturdy framework, except to remove dead or overcrowded wood. A mulberry tree can be kept to a tidy form by developing a set of main branches, and then pruning laterals to 6 leaves in July in order to develop spurs near the main branches. It is not advisable to prune the trees heavily since the plant is inclined to bleed at the cuts. Cuts of more than two inches in diameter generally do not heal and should be avoided at all cost. The bleeding will be less severe if the tree is pruned while it is dormant.

Pests and Diseases: Mulberries are generally free of pests and diseases, although cankers and dieback can occur. The ripe fruit is very attractive to birds, but there is usually enough fruit left over for harvesting.

Harvest: White and red mulberry fruits (and hybrid fruits) are ready for harvest in late spring. The fruit of black mulberries ripen in summer to late summer. The fruits of white mulberries are often harvested by spreading a sheet on the ground and shaking the limbs. A surprising quantity can be gathered from a comparatively small and young tree. Black mulberry fruits are more difficult to pick. As the berries are squeezed to pull them loose, they tend to collapse, staining the hands (and clothing) with blood red juice. Unwashed the berries will keep several days in a refrigerator in a covered container. The ripe fruits of the black mulberry contain about 9% sugar with malic and citric acid. The berries can be eaten out of hand or used in any way that other berries are used, such as in pies, tarts, puddings or sweetened and pureed as a sauce. Slightly unripe fruits are best for making pies and tarts. Mulberries blend well with other fruits, especially pears and apples. They can also be made into wine and make an excellent dried fruit, especially the black varieties.